Our Lead compound PrC-210

We engineered the ultimate free radical scavenger PrC-210, based on these three molecular principles:

A thiol site providing rapid, broad-spectrum radical scavenging.

Two positive amines enabling targeted protection of negative biomolecules.

A low molecular weight ensuring rapid bioavailability

Direct comparison between PrC-210 and other free radical scavenger:

Low Molecular weight (148 Da) enables immediate absorption and blood-brain barrier penetration

The thiol scavenging site rapidly quenches free radicals with high affinity and a broad spectrum of activity.

The two positively charged amines facilitate protective interactions with DNA, RNA, phospholipids, and proteins throughout the cell.

Higher molecular weight limits and delays absorption, and reduces penetrationacross the blood–brain barrier.

Hydroxyl scavenging sites quench free radicals more slowly, with moderate affinity and a narrower spectrum of reactivity.

Hydrophobic properties limit interactions with DNA, RNA, and proteins,promoting preferential accumulation in lipid membranes.

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